Study of biodegradable polymer/clay nanocomposite implanted in gastro intestinal (GI) tract fixation
| Autor: | YA-LUN LEE, 李亞倫 |
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| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 107 This research aim to control body weight and blood glucose of diabetic obesity rats by implant biodegradable polymer duodenal barrier, which is made by polycaprolactone/poly(D,L-lactic acid) blend clay nanocomposite. Obesity and type II diabetes is the serious medical problems in recent years. Surgery is still the gold-standard treatment for morbid obesity and obesity related type II diabetes, which changes the structure of the digestive tract and gastrointestinal physiology. But surgical risk and complication may cause the physiological and psychological stress of patients. Non-invasive therapy may be an alternative treatment for obesity and diabetes mellitus. Some research have already proved that implants a barrier, covering partial of the duodenum can alter intestinal hormones and reduce body weight and blood glucose. Polycaprolactone and poly(D,L-lactic acid) are two well-known biodegradable polymer, having great biocompatibility and fine mechanical properties. To enhance the mechanical properties of biodegradable polymer, polycaprolactone and poly(D,L-lactic acid) blend with nano-clay Laponite® under different content ratio. PCL/PDLLA/Laponite® nanocomposite has largest improvement of 109% in tensile test. Four weeks after duodenal barrier implant in intestine of diabetic obesity rats, body weight and blood glucose both have obvious improvement. Histopathological section report showed no acute symptoms of inflammation. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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