The association of corticomuscular coherence with motor development in early infancy

Autor: Hsiao-Feng Chou, 周曉鋒
Rok vydání: 2019
Druh dokumentu: 學位論文 ; thesis
Popis: 107
Introduction Corticomuscular coherence (CMC) quantitatively measures the frequency correlation between electroencehalography (EEG) and surface electromyography (EMG), as an indicator of functional corticospinal connectivity between the primary motor cortex and limb muscles. These methods are non-invasive and suitable for investigating fidgety movements in infancy. The aim of our study is evaluating the association between CMC and early motor development in infancy Methods Twenty infants who were 2-3 months old, normal-delivery birth participated this study. EEG was recorded from the primary motor cortex area (Cz). Surface EMG was recorded from the right and left tibialis anterior muscles. The motor development was evaluated using the Bayley Scales of Infant Development, third edition (Bayley-III) at 6-7 months of age. Results We enrolled 20 infants, mean aged 2.4±0.3months for recording of EEG and surface EMG, and analyzed CMC in 18 of them. Eleven out of the 18 neonates (61%) showed significant CMCs and distributed in all frequency bands. The majority frequency band of CMC significance was gamma band (7 infants). Fifteen subjects, mean aged 6.4±0.3months were followed by Bayley-III. All of these infants had normal development including borderline gross motor development in 4. If we proposed borderline development as delay, there was no significant association between in Bayley-III developmental results and CMC significance using Fisher''s exact tests. There was also no significant difference between gross motor scales in Bayley-III and CMC significance by independent student t-test. Conclusion Our study showed that the majority of normal infants were detected significant CMC at 2-3 months of age. Compared with the infants with borderline development, the sensitivity of normal development of infants is not high (53%). The availability of CMC is required by further study in developmental delay infants.
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