The Feasibility of Screening Test for Mycobacterium Tuberculosis Using Xpert MTB/RIF
| Autor: | YU, FANG-LAN, 余芳蘭 |
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| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 Tuberculosis is a chronic infectious disease and it is still common in the world today, especially in untapped and developing countries. Tuberculosis has almost no obvious symptoms in the early stages and it is easily overlooked. Therefore, it is relatively important that TB can be correctly and quickly diagnosed. Mycobacterium tuberculosis is transmitted through the air. Therefore, in laboratory inspection operations, it is necessary to consider how to avoid the negative pressure setting by air spreading and the operator's safety protection. The flood prevention work of the public security in Taiwan is facing many challenges. The correct and rapid inspection of tuberculosis is really an important part. However, the lack of TB inspection hardware facilities and insufficient protective equipment, high risk of TB inspection, and low investment return rate have caused the general hospitals and inspectors' willingness to engage in tuberculosis-related tests to be low, so they are seeking high sensitivity and convenient operation procedures. The inspection method, after screening most of the negative samples, relatively reduces the manpower required for inspection, thereby addressing the high risk of tuberculosis testing and the low willingness of inspectors to engage in tuberculosis-related tests, and on the other hand, evaluating their cost-effectiveness. A total of 36,674 Mycobacterium tuberculosis tests were collected from a medical center from January 2016 to December 2016. The sensitivity, specificity, and PPV were calculated and calculated. The correlations were calculated, together with the timeliness of reports and labor costs. The results showed that although the smear could be reported within 24 hours but the sensitivity was < 50%, the sensitivity of Xpert MTB/RIF was up to 90%, which was reported in about 2 hours, while the RIF drug was tested for its PPV and NPV also reached more than 92%. Xpert MTB/RIF test reagents are simple, fast and have good sensitivity, correctness, and can overcome the space and technical requirements. It is feasible to apply screening, but it is expected that the price is high and sensitive. Improvements and diversification of drugs can be further breakthroughs. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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