Feasibility of Using Mechanomyography Signal to Evaluate the Botulinum-Toxin Treatment Efficacy on Upper-Arm Spasticity

Autor: Lee, Hsuan-Chi, 李炫奇
Rok vydání: 2018
Druh dokumentu: 學位論文 ; thesis
Popis: 106
Spasm is one of the common symptoms of stroke patients, and it causes muscles producing involuntary tetanic contraction, which leads to a sudden muscle involuntary contraction. Patients will accompany by pain and uncoordinated muscle movements depending on the severity of muscle rigidity. Generally, in clinical application, Modified Ashworth Scale (MAS) is the most popular way to measure the tension and stiffness of the muscles. Recently, the study proposed the use of mechanomyography assisting with electromyography on post-stroke patients. In biceps muscle isometric contraction test, the frequency domain characteristics on stork patients are significantly different comparing with the normal people and obtain different mechanical properties on muscle. After the treatment of botulinum toxin, muscle spastic tension relatively decreased and improved. Therefore, we are look forward to seeing that this method will be used to assist in the existing medical spasms assessment methods to achieve a more complete diagnostic effect. In our research, we designed two different experimental methods to evaluate the degree of muscle tone with spasm. One was loading experiment of mechanomyography, the other was decay experiment. In the loading experiment, we extracted the features from filtered mechanomyographic signal and quantified the features’ changes as an objective index corresponding with the clinical spasm evaluation as the loading weight increased. In the decay experiment, we utilized two sensor covered on the muscle skin to measure the changes of decay ratio between sensors while vibrating energy was passing through the muscle and skin surface, and used it to evaluate the tissue softness after medical treatment. Furthermore, we found out it was unable to repeat our decay experiment results due to abnormal changes on the decay ratio caused by many factor, and also unable to consider it as a method to estimate tissue softness. After fully and prudential discussion with doctor, we presume that this experiment was not feasible applying on spastic patients.
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