Sedative effects of high dose buprenorphine as a post-operative analgesic in dogs
| Autor: | Che-Jung Hsu, 許哲榮 |
|---|---|
| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 Buprenorphine is a semi-synthetic thebaine derivative that broadly employed for analgesia in veterinary medicine. It is classified as partial μ-opioid agonist based on high affinity and low intrinsic activity to the receptor. Recent studies have demonstrated that buprenorphine acts as a full agonist with no ceiling effect on analgesia. However, administration of buprenorphine above the recommended dosage may induce greater adverse reactions. Therefore, the aim of this study is to evaluate the post-operative sedative effects of high dose buprenorphine in dogs. Fifteen male dogs from the NCHU-VMTH for castration were enrolled and randomized to either buprenorphine 40 (B40 group, n = 7) or 60 μg/kg (B60 group, n = 8). After anesthesia and rewarmed body temperature to over 37.8℃, relevant doses of buprenorphine for each group were intravenously administered for post-operative analgesia. Sedation was evaluated using VAS and a multi-dimensional sedation scoring system. Measurements along with vital parameters and pain scores were recorded at baseline (prior to treatment) and up to 12 hours after administration. Sedative effects rapidly elevated to maximum at 1 hour and then fell over time, significant increase in levels of sedation reached 4 to 6 hours after administration of both treatments. B60 group showed promotion of sedative effects and also prolonged the duration of action compared to B40 group; however, the enhancements were not significant among two treatments. No detrimental effects on cardiovascular and respiratory system were observed and none of the dog required rescue analgesia throughout the study. In conclusion, administration of buprenorphine at 40 and 60 μg/kg can significantly induced sedation. Either dose of buprenorphine provides sufficient analgesia for up to 12 hours after castration. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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