Cobalt-substituted hydroxyapatite/ titanium dioxide nanotube composites for biomedical application: Preparation and characterization
| Autor: | Ya-Hsu Chiu, 邱雅煦 |
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| Rok vydání: | 2018 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 106 Gadolinium ion-containing developers are quite toxic and possible cause serious complications. Therefore, through the hydroxyapatite with good biocompatibility are add the metal ions, previous studies have reported that the deposited of hydroxyapatite on TiO2 nanotubes can significantly affect the mechanism of nucleation. The electrolyte was prepared by dissolving 0.042M calcium nitrate and 0.025M ammonium dihydrogen phosphate in deionized water. A quantity of cobalt ion that would allow for 10%(mole%) substitution was added to the electrolyte. Cobalt-substituted hydroxyapatite (CoHA) was synthesized on pure titanium and TiO2 nanotube substrates by direct current and pulse current, respectively. The results show that titanium dioxide nanotubes were prepared by pulsed anodic oxidation to obtain a nanotube structure with a flat arrangement. The cobalt-substituted hydroxyapatite powders were observed to obtain spherical nanoparticles. Use MG63 evaluation biocompatibility showed that the CoHA had good biocompatibility and no significant inhibition cell growth. The magnetic analysis showed that the CoHA deposited on the nanotubes did significantly affect the magnetic performance and increased the saturation magnetic field strength. Application of magnetic resonance imaging, addition of cobalt ions does increase the relaxation rate of T2-weighted imaging, enhance the contrast of the image and deposit CoHA in the nanotubes to obtain a higher relaxation rate. it can produce the effect of image differentiate to present better image sensitivity. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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