Multicomponent Synthesis of Pyrrolizidine and Azepine/Coumarin-Fused Derivatives
| Autor: | PENG, YU-TING, 彭郁婷 |
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| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 In this thesis, we report the design, synthesis, and characterization of pyrrolizidine and azepine/coumarin-fused compounds via multicomponent reactions and subsequent evaluation of their potential antibacterial activities. In the first part, microwave-assisted three-component reactions of L-proline, benzaldehyde and 1,3-indandione obtained the pyrrolizidine derivatives. In the second part, the azepine/coumarin-fused seven-membered heterocyclic derivatives were prepared by condensation of 3-amino-4-hydroxycoumarin with acetophenone in a pseudo three-component reaction manner. The scope and limitation of these synthetic methods along with the plausible mechanisms are discussed. Some azepine/coumarin-fused compounds were found to possess moderate antibacterial activity against E. coli. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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