AC-10 Inhibits EMT Via The Modulation of Wnt/β-catenin and Inhibition of Smad2 Signaling Pathways in Triple-Negative Breast Cancer Cells
| Autor: | Jian-You Pan, 潘建佑 |
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| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 AC-10 is a well-known traditional Chinese medicine in Taiwan. AC-10 possesses many bioactivities including anticancer activity. AC-10 showed anti-breast cancer effect induced breast cancer cell apoptosis, however, the metastasis was not clearly studied. TGF-β is a pleiotropic, anti-inflammatory cytokine and a pivotal regulator of a wide range of cellular processes, including cell cycle, proliferation, differentiation, epithelial-to-mesenchymal transition (EMT) and metastasis. In cancer cells, EMT confers tumor cells with a distinct advantage for metastatic dissemination. In this study, MDA-MB-231 cells were treated with AC-10 (0-60 μg/mL) for 24 h. The protein levels of E-cadherin in whole cells were determined by Western blotting. AC-10 up-regulates E-cadherin expression. Results showed that AC-10 inhibited EMT via modulation of Wnt/β-catenin and inhibition of Smad2/3 signaling pathways on triple-negative breast cancer (MDA-MB-231) cells in vitro and in vivo. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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