Relationship between symptom severity, heart rate variability and cognitive impairment in patients with obstructive sleep apnea.
| Autor: | CHEN, TING-YIN, 陳亭吟 |
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| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 The research has two parts. It is going to probe the correlation among the severe levels of the symptom, the heart rate variability(HRV), and the defect of cognition function for patients with obstructive sleep apnea(OSA). The first study issue is to discuss the correlation between the severe levels of the symptom and the HRV for patients with OSA. The target objects of the first part are 1,011 recalled cases from the center of the sleep disorder in Hualien Tzu Chi Hospital. The collected patients are general index (gender, age, and body mass index(BMI)), the index in severe levels of the symptom (Apnea-hypopnea Index, AHI), and the index in HRV (including time domain analysis and frequency domain analysis.) The statistical method is to figure out the correlation of the indexes of sleep apnea, AHI and HRV by simple linear regression; then, pick up the noticeable index and correct the interference variable (general index) by multiple linear regression method; finally, probe the correlation between the two items. The research outcome is that AHI has something to do with the four frequency domain indexes, which are the whole HRV, the index of sympathetic nerve, the index of parasympathetic nerve, and the index of autonomic nerve active balance. It means if the sleep apnea happens more, the patients get sympathetic nerve stimulated, parasympathetic nerve calmed, and the whole HRV risen because of the oxygen deficiency. HRV is changed by breathing regulation. It also indicates the severe level of OSA inter-affects the HRV. The second study issue is to discuss the correlation between the HRV and the defect of cognitive function for patients with OSA. The target objects of the second part are to enlist around 120 patients with OSA from the division of thoracic in center of the sleep disorder in Hualien Tzu Chi hospital. Before therapy, the research collects the patients’ general index (gender, age, and BMI), the index in severe levels of the symptom (AHI), the index in HRV (time domain analysis and frequency domain analysis), and the index of cognitive function (Psychomotor Vigilance Test(PVT), Flanker task and Stroop task) The statistical method is to figure out the correlation of the index in HRV and index of cognitive function by simple linear regression; then, pick up the noticeable index and correct the interference variable (general index and severe levels of the symptom) by multiple linear regression method; finally, probe the correlation between the two items. The research outcome is the sympathetic nerve index, parasympathetic nerve index, and autonomic nervous system balance index of the HRV have nothing to do with the major indexes of cognitive function. It means the HRV and cognitive function are two independent dimensions. The possible reason is HRV and cognitive function belong to different nerve system. The HRV belongs to the regulation of autonomic nerve system. The cognitive function is the trend of central nerve function in brains. They are not evidently correlated. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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