The Effect of Galectin-3 and IL-22 Signaling on Antimicrobial Peptides Gene Expression in Intestinal Epithelial Cells
| Autor: | Guei-Yun Cheng, 鄭貴云 |
|---|---|
| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 Galectin-3 (Gal-3) is known to exert a lot of biological function. Expression of Gal-3 is significantly downregulated in the gut of patients with inflammatory bowel disease (IBD). Interleukin-22 (IL-22) is known to protect against colitis through enhancing the production of antimicrobial peptides (AMP), such as Reg3β/3γ and S100A8/A9. Binding of IL-22 to its receptor activates Jak1/Tyk2-STAT3, Akt and MAPK signaling pathways. It has been reported that Gal-3 and IL-22 are important to maintain the intestinal homeostasis. We hypothesize that Gal-3 may participate in IL-22 signaling and regulate the functions in intestinal epithelial cells (IECs). In our study, Gal-3 seems not regulate the three major IL-22 signaling pathways. Although Gal-3 is not involved in regulating Reg3b/3g expression, it negatively regulates IL-22-induced S100A8/A9 expression in colon. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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