Study of Biological Resonance Waves applied toimproving Diabetes Mellitus

Autor: Wen-Chieh Chang, 張文杰
Rok vydání: 2017
Druh dokumentu: 學位論文 ; thesis
Popis: 105
Diabetes Mellitus is an essential disease of metabolism for medicine nowadays, the patients of DM in 2017 will reach more than 400 million globally with a steady growth rate. The prevalence of this mono chronic disease would be about 5.3% among the population of total 7.5 billion in the world. The two main medical treatments of DM are oral drug and insulin injection which have apparent side effects and mostly derive to liver and kidney failures in the aftermath. Therefore, a novel treatment with less side-effect and with no harm for liver or kidney is in demand. In this study, we develop a non-invasive physical therapy of bRWs (biological Resonance Waves) including the device and treatment through different levels of verification from cell, animal, to clinical trial for the medical requirements. This thesis firstly focuses on the hardware and software design, and implementation of bRWs technology with MENS (MENS, Microcurrent Electrical Nerve Stimulation), as well as the essential frequencies applied for it are discovered from the data mining of scientific induction for optimization to biomedical efficacy. Based on a bottom-up strategy, HaCaT cell is applied to investigating energy utilization of mitochondria in vitro affected by bRWs to study the capability of glucose regulation. Then, the pre-clinical animal assay of DM induced by STZ method shows a great improvement in HbA1c and OGTT to help on the verification of in vivo efficacy for DM and provides the possible clues for toxicity and medical mechanism. Finally, a 20 month period and 72 enrollments of clinical trial permitted by IRB and TFDA to run for the last mile of this bRWs’ study proves a solid improvement of DM on the primary endpoint of HbA1c to achieve this systematic investigation of bRWs therapy.
Databáze: Networked Digital Library of Theses & Dissertations
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