Dietary resistant maltodextrins complex on plasma lipid and adipose tissue in SD rats
| Autor: | Liou, Sin-Ya，, 劉心雅 |
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| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 Obesity and associated metabolic disorders are major public health issues around the world. Today, there are numerous dietary supplements for weight management, in which resistant maltodextrin (also known as soluble corn fiber), white kidney bean extract and garcinia cambogia extract have been widely used. Nevertheless, the synergy effect of the three substances remains unclear. The purpose of this study was therefore to investigate the effects of the combination of resistant maltodextrin, white kidney bean extract and garcinia cambogia extract (referred to as the resistant maltodextrin complex) on blood lipids and adipose tissue in rats with obesity induced by a high fat diet. The research model was described as follows. Male Sprague-Dawley (SD) rats were put on a high fat diet (10 % butter + 0.3% cholesterol) to induce obesity. In the induction period, the rats were first divided into two groups: (1) normal diet control (NC) and (2) high fat diet (HF). After feeding for six weeks, obesity was successfully induced and the rats were re-divided into three groups: (1) NC, (2) HF and (3) high fat diet + resistant maltodextrin complex (S), for an experiment, which lasted 12 weeks. During the feeding period, the rats were on free diet. The experimental results showed significantly reduced food consumptions and increased losses of body weight and adipose tissue weight in the S group. A blood plasma analysis further showed the resistant maltodextrin complex was able to reduce the sum of very low density lipoprotein and low density lipoprotein cholesterol (VLDL-C + LDL-C) and significantly lowered the levels of insulin and HOMA-IR. Furthermore, it was able to suppress the activity of lactase and sucrase in the small intestine. In terms of lipids, it was able to significantly reduce the levels of triglycerides (TGs) in the liver and perirenal fat and enhance the activity of HSL (hormone sensitive lipase) as well as accelerate lipolysis in fatty tissue. In addition, an analysis of fecal lipids showed it was able to significantly increase the amounts of TGs and cholesterol excreted together with feces. To sum up the aforementioned results, it is inferred that the resistant maltodextrin complex may be able to suppress absorption of carbohydrates in the intestines for less energy absorption, enable less fat accumulation through enhanced HSL activity and reduce the lipid content in tissue by increasing the amounts of TGs and cholesterol excreted together with feces. Therefore, the resistant maltodextrin complex has the potential to make improvements for obesity and associated metabolic disorders. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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