Enantioselective Arylation of Aliphatic Ketoamides Catalyzed by Rh(I) /Chiral Bicyclo [2.2.1] Diene Ligands
| Autor: | Chen, Ming-Liang, 陳明良 |
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| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 In this thesis, a highly enantioselective rhodium-catalyzed 1,2-addition of aryl boronic acids to aliphatic α-ketoesters and aliphatic ketoamides using Rh-catalyst comprising of a chiral bicyclic [2.2.1] diene ligand L1d is described. This transformation provides chiral tertiary alcohol products with up to 93% yield and 95% ee, product 84 is used for the concise synthesis of the VLA-4 antagonists intermediate. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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