Synthesis of Tetrahydroisoquinoline Derivatives Molecular Library and Gold-Assisted Synthesis of Isoquinolino[1,2-a]isoquinoline Derivatives
| Autor: | Liu, Shih-I, 劉士毅 |
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| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 Use Pictet-Spengler reaction to synthesize tetrahydroisoquinoline then react with isocyanate, isothiocyanate, isoselenocyanate via [3 + 2] cycloaddition to obtain imidazo[1,5-b]isoquinoline, or react with chloroacetyl chloride then follow by primary amine to obtain pyraz[1,2-b]isoquinoline, and build up the molecular libraries. Gold-Assisted one-pot two-step synthesis of isoquinolino[1,2-a]isoquinoline. First step undergo Pictet-Spengler reaction, then second step follow by gold catalyze 6-endo-dig cyclization to give the isoquinolino[1,2-a]isoquinoline. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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