Visualization of Swallowtail Sign Using 3T MRI
| Autor: | Ming-HongHe, 何明鴻 |
|---|---|
| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 Recently, many MRI studies have reported that the swallowtail sign at substantia nigra can be visualized in healthy substantia nigra and which is unilaterally or bilaterally absent in PD patient. But there is no study focuses on the clarity of swallowtail sign. Our study aims to investigate swallowtail sign in health subject and compare quality of different MRI imaging methods and different age groups at 3T. The MRI data were acquired by 3D uni-polar multi-echo gradient echo sequence. In order to reduce scan time, limited volume coverage of brain data was acquired in experiments. The MRI imaging method included T2*-weighted image, T2* mapping, susceptibility weighted image, quantitative susceptibility mapping and FLAIR are then post-processed. In addition, we use clustering method to decompose substantia nigra in order to clearly distinguish nigrosome-1 and utilize rating to quantify the quality of swallowtail sign. In the comparison between different MRI imaging method, T2* mapping is significantly better than magnitude image in visualization of swallowtail sign and SWI is significantly better than magnitude image in elder group. In our study, we investigate swallowtail sign in health subject at 3T in detail. This study will serve as a baseline for future studies using the swallowtail sign as a biomarker for PD. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|