The Blood and Biochemical Analysis of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice
| Autor: | Yu-Cheng Li, 李育誠 |
|---|---|
| Rok vydání: | 2017 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 105 Psoriasis is an immune-mediated chronic skin disorder. It affects about 125 million people worldwide. The prevalence of psoriasis in the adult population is estimated at 0.91% in the United States to 8.5% in Norway. The characteristics of psoriasis include abnormal hyperplasia in epidermis, production of plaques and inflamed dander, and immune cell infiltration symptoms. Although psoriasis is not an infectious disease, social and quality of life are affected in patients with psoriasis. At present, the real etiology of psoriasis is still unclear, but may relate to a number of factors. Imiquimod (IMQ), a toll-like receptor 7 (TLR7) ligand, is a potent immune-modulatory agent. Studies have indicated that topical application of IMQ could induce psoriasis-like skin inflammation in mice. Recent studies have indicated some blood or biochemical profile, such as mean platelet volume (MPV)、platelet distribution width (PDW) and C-reactive protein (CRP) are significant changes in psoriasis patients. In this study, the blood and biochemical profile of mice with IMQ-induced psoriasis-like skin inflammation were examined. We observed that MPV, PDW, mean corpuscular volume (MCV), red cell distribution width standard (RDW-SD), red cell distribution width coefficient of variation (RDW-CV) and CRP are increase. In contrast, mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), biochemical projects cholesterol (Cho), low-density lipoprotein (LDL), High-density lipoprotein (HDL) and Albumin (Alb) are significantly decrease. These changes are similar to blood and biochemistry profiles of human psoriasis. Thus, IMQ not only induces mice with psoriasis-like skin inflammation which similar human psoriasis, the blood and biochemical changes are also similar to human psoriasis. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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