PREPARATION OF DMA-TRIS-NVP SILICONE HYDROGELS FOR CONTACT LENS MATERIAL
| Autor: | NGUYEN HUYNH QUANG DIEU, 阮黃光耀 |
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| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 104 A silicone hydrogel was synthesized through photoinitiated free radical polymerization process using dimethylacrylamide (DMA), tris-(trimethyl-silyl-propyl-methacrylate) (TRIS), N-vinylpyrrolidone (NVP), ethylene glycol dimethylacrylate (EGDMA) as crosslinker and PI1173 as photoinitiator. The equilibriumwater content (EWC) and oxygen permeability was adjustable by changing the ratio between hydrophiclic monomers DMA, NVP and hydrophilic monomer TRIS. The results indicated that higher NVP content led to a higher water content, lower contact angle, lower elastic modulus and higher protein adsorption. In term of oxygen permeability, at an NVP concentration of 25%, the silicone hydrogel sample exhibited a Dk value of 46 barrers. In addition, these silicone hydrogels were confirmed non-cytotoxic according to a in vitro L929 fibroblast assay. In summary, the results illustrated that the DMA-TRIS-NVP copolymer was a good candidate for contact lens material application due to high hydrophilicity, excellent optical transparency, improved oxygen permeability, good wettability and biocompatibility. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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