Investigate the Effects of Environmental Enrichment for Post Traumatic Stress Disorder (PTSD) in Animal Model
| Autor: | CHANG-HAO ChEN, 陳張豪 |
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| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 104 Post-traumatic stress disorder (PTSD) is a complex disease that is defined by individual experience to intense, life-threatening trauma then lead to various physical and psychological abnormalities. The re-experiencing and avoidance symptoms of the disorder may hinder daily life in PTSD patients, and they develop additional debilitating symptoms, including persistent anxiety, exaggerated startle, and cognitive impairments. Environmental enrichment has been showed to enhance learning and memory, improve neurological diseases and anxiety behavior. Furthermore, previous research also found that estrogen may correlate with the stress response. In the present study, we want to investigate the effects of environmental enrichment on anxiety and depress behavior before or after survival stress in male rats. Furthermore, the concentrations of estradiol during experiments were detected. In this study, we breed rats in different environment and observe the effect of PTSD related symptoms. Therefore we use eight-week-old SD male rats expose to survival pressure, and then divided into three groups: control, isolate feeding (ISO) and enrich environment (EE). We use the behavioral tests (open field test and tail suspension test) to determine the level of anxiety and depress in animals. Serum samples of all animals were also collected through tail vein for hormone analysis (estrogen) before and after survival stress. From our results in tail suspension test and open field test, the animals of EE before stress and Continue EE could resistant to stress. However, the group of Continue ISO showed more depress in tail suspension test. On the other hand, the group of EE before stress showed more anxiety in open field test. In the results of hormone test, we found survival stress enhances E2 level in male rats, and animals of EE group in second bitch showed less enhanced. Therefore, our result showed enhanced anxiety, depress and serum estradiol levels after survival stress. Environmental enrichment could constant these change. Finally, we purpose environmental enrichment may be one of the improved ways for PTSD. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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