Lhx2 Controls the Timing of Neurogenesis during Cortical Development.
| Autor: | HSU, CHIA-LING, 許家齡 |
|---|---|
| Rok vydání: | 2015 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 104 The cerebral cortex is the most highly evolved brain structure and responsible for cognition, consciousness, perception of sensory stimuli, and execution of motor actions. Cortical neurogenesis is the process of producing neuron from the cortical progenitors. To give rise to an optimal number of cortical neurons and functional brain, the balance between proliferation and differentiation of cortical progenitor has to be tightly regulated. Microcephaly patients usually exhibit learning defects are likely due to the decreased number of neurons in their brain. The deletion of Lhx2 from the progenitor at the onset of neurogenesis by Nestin-cre leads to precocious neuronal differentiation and much smaller brain, about 50% of the normal brain size, with decreased number of neurons. In my study, I major focus on four aspects to study the regulation of cortical neurogenesis. (I) Lhx2 control the balance of cortical progenitor proliferation and differentiation. (II) Lhx2-dependent molecular mechanism for progenitor proliferation. (III) Events associate with progenitor proliferation/cell fate determination. (IV) Brain size and timing of neurogenesis. Our results indicate that Lhx2 controls the size of cerebral cortex by regulating the initiation of neurogenesis, delaying radial glia differentiation and modulating the cell division mode of cortical progenitors. We further investigate the underlying mechanism, we found that Wnt/ β-catenin signaling pathway failed to maintain progenitor proliferation in the absence of Lhx2. Thus, Lhx2 is required for β-catenindependent progenitor proliferation and controls the timing of cortical neurogenesis. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|