Effect of methomyl poisoning dose on the variation of its concentration in rats over time
| Autor: | Ming-Shian Lin, 林明賢 |
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| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 104 In order to understand the change which pesticide poisoning in rats in this paper, combining forensic toxicology and pharmacokinetics is the idea to design this experiment. Use gastric tube to deliver pesticide methomyl into SD rat’s stomach by different doses. The purpose is to study the residual concentration with time of methomyl in the rat’s body. And the result may be used as pesticide poisoning autopsy judging reference for forensic community. Use a commercial pesticide 24 % methomyl solution to implement the experiment. Methomyl concentration in the gastric contents gradually decrease with time increasing. The concentration in organs besides lung increase first and then decrease over time. The highest concentration approximately reach in 7 to 14 days. The reason is to deduce from diffusion along the concentration gradient, death cycle, degradation and destruction of poison and the action of microorganisms.The influence of diffusion along the concentration gradient, death cycle and the action of microorganisms is more powerful than degradation and destruction of poison in 1 to 14 days in poisoning. After 14 days, the influence of the degradation and destruction of poison is more powerful than the inference of diffusion along the concentration gradient, death cycle and the action of microorganisms. Therefore, the concentration of organs slowly decrease.Besides because the diffusion along the concentration gradient of stomach contents spread out, so the concentration of the stomach contents is downward trend. The result show that feed animals methomyl of poisoning fatal dose will bring about the concentration of the stomach contents decrease and the concentration distribution in other organs are not the same. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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