Synthesis of Triazine Dendrimers and Study of Their Interaction with Cosmetic Ingredients
| Autor: | Chia-Jung Tu, 杜佳蓉 |
|---|---|
| Rok vydání: | 2016 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 104 Among the dendrimers, melamine based dendrimer (also called triazine dendrimer) is potential and considering in biomedical application owing to the simplicity and variety in its synthetic route and various products could be easily obtained by temperature-controlling process. In the recent past, dendrimers are being studied as drug carriers for drug delivery. In this research, the triazine dendrimers with Piperazine and 4- (aminomethyl)piperidine as linkers were prepared through solid phase synthesis processes to offer generation zero (G0) to generation two (G2). In general, our approach significantly reduced the product complexity and also achieved the yield enhancement to 70%. In the drug encapsulation test, there are two groups of compounds were used as guest molecules to determine the interaction between them with host molecules, triazine dendrimers. Group one is three common sunscreens with benzene ring and carbochain in their structures. Another group is non-sunscreen compounds containing thymine, kojic acid and (R)-(-)-Mandelic acid. The binding were evaluated by isothermal titration calorimeter (iTC 200 ) and Nuclear Magnetic Resonance (NMR), however, the binding capacities were only determined by the chemical shift of guest molecules in NMR. The chemical shift of sunscreens changes around -0.0010-0.013 ppm and another group changes around -0.005-0.052 ppm. Among them, the thymine binding with PITD-G2 through hydrogen bonding gave +0.052 ppm change to present the strongest interaction. Therefore, it demonstrates the interaction ability between thymine and the rigid PITD-G2 is best. This study has proved that the design of the triazine dendrimers can be combined with the drug molecules, and NMR can clearly determine a combination of Host-and- Guest reaction. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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