The Effect of Parvoviridae VP1 unique Re-gion in H9c2 Cardiomyocytes
| Autor: | Di-Wei Lin 林迪威, 林迪威 |
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| Rok vydání: | 2015 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 103 Human parvovirus B19 (B19V) and Human Bocavirus (HBoV) belong to Parvovirdae. Their capsids consist of two structural proteins, VP1 and VP2. In the end of the B19V-VP1 protein are identical except for 227 amino acids and at the end of the HBoV-VP1 protein are identical except for 129 amino acids, which are called VP1-unique region (VP1u), both of them contain sPLA2 enzyme activity. Previous studies show that B19V may trigger heart disease, such as myocarditis, cardiomyopathy, and pericarditis. Moreover, B19V-VP1u play an important role in B19V infection and its sPLA2 activity is related to the disease, such as myocarditis. Therefore, we intend to investigate the effects of the Parvovirdae capsid protein on H9c2 cardiomyocytes. Here, we report that inflammatory damage induced by B19V-VP1u with sPLA2 activity in cardiac H9c2 cells. Therefore, the sPLA2 activity of VP1u may involve the mechanisms of B19V-related myocarditis. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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