Biocompatibility and Drug Release Behavior of Sodium Alginate /Pectin Hydrogel Beads Containing Curcumin
| Autor: | CHANG,CHIA-JUNG, 張家榕 |
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| Rok vydání: | 2015 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 103 Curcumin, a hydrophobic phenolic compound, has been shown to possess several pharmacological activities such as antioxidant, anti-inflammatory, antiviral, antifungal and anti-tumorigenic activities. In this study, the mixture of sodium alginate (ALG) and pectin (PEC) was crosslinked with Ca2+ to form pH-sensitive hydrogel beads. The swelling and pH-sensitive properties of the sodium alginate/pectin (ALG/PEC) hydrogel beads were tested different pH environments. The drug release behaviors of the loaded curcumin ALG/PEC hydrogel beads were investigated in simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). In addition, DPPH radical-scavenging and total phenolic content assays were employed to measure antioxidant activities of the curcumin-loaded ALG/PEC hydrogel beads. Finally, the cytotoxic effects of the curcumin-loaded ALG/PEC hydrogel beads on L929 mouse fibroblasts were evaluated by MTT assay. The results suggested that the curcumin-loaded ALG/PEC hydrogel beads may be a potential carrier for oral administration of site-specific drugs. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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