Timing of Retinopathy of Prematurity Laser

Autor: Po-Chen Tseng, 曾柏宸
Rok vydání: 2014
Druh dokumentu: 學位論文 ; thesis
Popis: 102
Purpose To determine if the time to treatment was significantly correlated to any risk factors in retinopathy of prematurity (ROP) at a single, tertiary care NICU (neonatal intensive care unit). Methods Data from a retrospective cohort of all newborn infants screened for ROP from July 2008 to March 2012 were analyzed. Newborn infants were identified for ROP screening in the Mattel Children’s Hospital NICU at Ronald Reagan UCLA (University of California, Los Angeles) Medical Center according to standard criteria, including gestational age less than 32 weeks, birth weight less than 1500 grams, or a complicated NICU course as determined by the NICU clinical team. Newborn infants that involved treatment-requiring ROP were included in the study and were reviewed for the following information: gestational age, birth weight, gender, maternal age, presence of multiple birth subjects, the use of prenatal maternally administered steroids, APGAR scores (Appearance, Pulse, Grimace, Activity, and Respiration), duration of intubation, and significant comorbid conditions. The time to treatment was examined using a multivariable analysis that controlled for confounders. Results In a 45 month period, 184 newborns were screened for ROP. 56 infants exhibited treatment-requiring ROP were included in this study. The mean gestational age was 25.88 weeks. The mean birth-weight was 803.43 grams. There were 32 (57.1%) males and 24 (42.9%) females. There were 39 (69.6%) singleton births and 17 (30.4%) multiple births. 49 (87.5%) of them had plus disease and 39 (69.6%) had ROP worse than or equal to stage 3. The mean postmenstrual age at treatment was 36.96 weeks (range 31 to 50.43 weeks, standard deviation 3.93 weeks) and the mean time from birth to treatment was 77.55 days. The mean maternal age is 31.4 years and ranges from 18 to 48 years. Linear regression revealed significant factors correlating to time to treatment were: gestational age, birth-weight, APGAR 1, APGAR 5, maternal age, multiple birth and female gender. Conclusion Older gestational age, smaller birth-weight, lower APGAR scores at 1 minute, older maternal age, multiple birth and female infant were correlated to shorter time interval from birth to ROP treatment.
Databáze: Networked Digital Library of Theses & Dissertations
Externí odkaz: