Synthesis of Potassium Peptidyl Trifluoroborates and their Analogs (I);Synthesis of Boron-containing Amines by Modified Gabriel Synthesis (II);Synthesis of Multiple Boron-containing Analogs via Ugi Reaction (III)
| Autor: | Ting-Ju Lin, 林庭如 |
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| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 Synthesis of Potassium Peptidyl Trifluoroborates and their Analogs (I):In this research, we have designed and synthesized two series of boron-containing analogues. These compounds could be easily synthesized and purified via simple synthetic operations. Synthesis of Boron-containing Amines by Modified Gabriel Synthesis (II):In this project, we have discovered the optimal synthetic conditions for the synthesis of boron-containing primary amines. Further, we have successfully demonstrated the utilization of these boron-containing primary amine building blocks to generate series of boron-containing Ugi analogues in moderate to good yield. Synthesis of Multiple Boron-containing Analogs via Ugi Reaction (III):In this project, we have successfully synthesized series of multiple boron-containing Ugi analogs. The synthetic methods we have developed provide a simple and efficient protocol to generate series of novel compounds. We’ve found that, if the starting material contains an electron-withdrawing group (EWG) (i.e. -F), the reaction temperature requires to be 60oC. On the other hand, when the electron-donating group (EDG) (i.e. -OMe) is present, a higher reaction temperature (65oC) is required. Interestingly, when neither EDG nor EWG is present, only moderate heating condition (50oC) is necessary. The synthesized boron agents are currently being evaluated for their potential in BNCT application. The result will be reported in due course. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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