Research on Injectable Calcium Phosphate Cement Adding With Binders
| Autor: | Wei-Lun Fan, 范瑋倫 |
|---|---|
| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 This study aims to develop an injectable calcium phosphate bone cement injection device directly injected locally and fast curing, can be used as drug delivery adjuvant therapy containing growth factors promote the formation of new bone and improve bone bonding properties to Tetracalcium phosphate (TTCP) and Dicalcium phosphate (DCPA) as a main component formulation design and add hydroxyapatite (HAp) as a seed to accelerate the rate of conversion of anhydrous citric acid, and (CA), the bone can be shortened cement curing time, increase strength, after adding different proportions of methyl cellulose (MC) and polyvinylpyrrolidone (PVP) into calcium phosphate cement binder within, to improve the performance of calcium phosphate bone cement injection, then disodium hydrogen phosphate solution as a binding agent made of composite material. Experimental results show that adding methyl cellulose (MC) and polyvinylpyrrolidone (PVP) adhesives, do basic physical properties, biocompatibility testing and drug controlled release experiments, showing the injection of PVP from MC adhesives and adhesives content increased and decreased, but the MC more, need the more hardened liquid to form a dough-like. Rupture strength increases with the decrease binder content MC, MC no significant effect on the proportion of curing time. Conversely PVP binder added, rupture strength increases with increasing content of PVP binder. And more than 5% PVP binder, bursting strength affect not obvious. Add adhesives for composite materials after immersion test, by observing the microstructure of the specimen surface, you can see the specimen surface will form hydroxyapatite (HAp), cytotoxicity tests are showing toxic materials. Controlled drug delivery system to display material within 24 hours soaking, drug controlled release rate rose to 10 percent; With the increase of immersion time, the subsequent release of the case show a slow rise in the steady state, we can see that the material is suitable as a drug carrier. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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