Associations of Single Nucleotide Polymorphisms in Dopamine-Related Genes with Developmental Variations in Preterm and Term Children

Autor: Nai-Jia Yao, 姚乃嘉
Rok vydání: 2014
Druh dokumentu: 學位論文 ; thesis
Popis: 102
Background and Purpose: Although dopamine-related genes may involve in the neurotransmission of cognitive, sensori-motor and behavioral systems, the information concerning their role in various developmental functions in preterm and term children has been limited. The purpose of this study was therefore to examine the associations of dopamine-related genes with mental and motor development in preterm and term children and to predict the development of preterm children using genetic risk scores. Methods: This study included 404 preterm children and 118 term children to collect their buccal cell samples of whom 201 preterm children and 111 term children have been prospectively assessed the mental and motor development using the Bayley Scales of Child Development-Second edition at 6, 12, 18, 24 and 36 months of age. The buccal cells samples were genotyped for 15 single-nucleotide polymorphisms (SNPs) of dopamine-related genes (DRD2, DRD3, DAT1, COMT and MAOA). Results: One SNP of DRD3 gene (rs167771), one SNP of DAT1 gene (rs2550948) and eight SNPs of MAOA gene (rs12843268 as the tagger) were significantly associated with the mental raw scores in preterm children between different genotypes with longitudinal analysis after false discovery rate corrections. The linkage disequilibrium (LD) block which covered all the eight markers of MAOA gene showed strong relationship (all D’ > 0.9 and r2 > 0.8). A genetic risk score formed by the dopamine-related genes was significantly associated with the mental development in learning set of preterm children, but such a relation did not reach statistical significance in testing set. Conclusions: The DRD3, DAT1 and MAOA genes may play a role in the mental development in preterm children.
Databáze: Networked Digital Library of Theses & Dissertations
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