Feasibility Study on Noninvasive Spectrophotometric Measurement of Glycated Hemoglobin for Diabetics
| Autor: | Yin-Lin Lu, 盧盈霖 |
|---|---|
| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 Glycated hemoglobin (HbA1c) is an important maker in diabetes diagnosis and disease status tracking. In this study, we demonstrate the advantage of using absorption spectroscopy technique for glycated hemoglobin (HbA1c) quantitation. By the ratio of selected absorption peaks, the concentration of HbA1c can be easily determined. Our experimental result shows that absorption spectroscopy is not only a sensitive method in HbA1c detection, but also a high potential technique in developing a noninvasive, rapid and cost effective diabetes monitoring device with. In our experiments, in order to establish the HbA1c concentration can be detected by spectral, we used the feature peaks of oxy-Hb, deoxy-Hb and metHb to calculate the peak ratio. As the results shown, we demonstrated that different HbA1c levels can be detected by spectral measurement system, and the calibration curve had 98% linearity in 1% to 12% HbA1c levels. In addition, the calibration curve had 97% linearity in 3% to 12% HbA1c levels of phantom spectrum by using the diffuse reflectance spectroscopy in noninvasive measurement experiments. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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