Expression of T and Tn antigen in head and neck squamous cell carcinoma
| Autor: | Hao-Yun Huang, 黃浩雲 |
|---|---|
| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 N-linked glycoproteins and O-linked glycoproteins are two main glycoproteins in human cells. Tn and T antigens are the first two glycan units on O-linked glycan chain. Aberrant glycosylation is commonly found in tumors. Many studies have reported an increased Tn and T antigen expression is associated with tumor cell malignancy. However, the underlying mechanism resulting in altered Tn and T antigen expression in tumor malignancies are still poorly understood. In this study, we investigated the expression of the Tn and T antigens in 175 head and neck squamous cell carcinoma patients by immunohistochemistry staining with Vicia villosa agglutinin (VVA) lectin, specific for Tn antigen; and peanut agglutinin (PNA) lectin, specific for T antigen recognition. Our results indicate 71% of the patients display higher Tn antigen expression levels in the tumors compared with the corresponding non-tumor tissues; and 69% of the patients exhibit higher T antigen expression levels in the tumors compared with the corresponding non-tumor tissues. Furthermore, we examined whether Tn and T antigen expression levels correlate with HNSCC clinical pathophysiology. Patients identified with low T antigen expression levels were associated with lymphovascular invasion (LVI), extracapsular spread (ECS), and advanced N stage (P |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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