Risk Factors of Dengue Hemorrhagic Fever in Taiwan, 2003-2013
| Autor: | Ying-Tzu Liu, 劉英姿 |
|---|---|
| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 Background and Objectives: Dengue fever is an important infectious disease in southern Taiwan. If complicated with dengue hemorrhagic fever, dengue can lead to death. Currently, the pathogenesis of dengue hemorrhagic fever has not yet been fully understood. The goal of this study was to examine the risk factors of progression to dengue hemorrhagic fever after acquiring dengueinfection, and the predictors of mortality after developing dengue hemorrhagic fever, using epidemiologic study methods. Method: All of the confirmed indigenous dengue fever and dengue hemorrhagic fever cases reported to notificable infectious diseases surveillance system during 2003-2013 were included in this study. The study was divided into two parts. (1) Case-control study that was aimed to examinethe risk factors of progression to dengue hemorrhagic fever after acquiring dengueinfection. Cases included all notified patients with dengue hemorrhagic fever during the study period. Controls were randomly selected from all notified patients with dengue but without hemorrhagic fever during the same period, individually matched by onset month and residential country in 1:4 ratio. (2) Cohort study that retrospectively tracked the outcomes of all notified patients with dengue hemorrhagic fever toanalyze the predictors of mortality. Result: A total of 142 dengue hemorrhagic fever cases and 568 controls were included in the case-control study. Multivariate conditional logistic regression analysis showed that age over 60 years (OR = 4.53, P |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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