Investigation of the Detection on J-coupled Metabolites using Point-Resolved Spectroscopy Asymmetry Technique by Simulation.
| Autor: | Li-Jhen Jheng, 鄭力禎 |
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| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 Magnetic Resonance Spectroscopy (MRS) has been used widely to quantify metabolite concentrations for clinical systems. However, some spectra in clinical application are obscured by stronger, overlapping resonances, and made the analytic and observation of these metabolites more difficult. In order to improve this situation, simulation was performed to generate spectra with PRESS asymmetry technique which helps to distinguish the strongly coupled metabolites. The experimental parameters were also optimized for these metabolites by this simulation. PRESS asymmetry technique relies on strongly coupled signal modulation by changing the timing between refocusing pulses, and obtaining one spectrum of which singlets and weakly coupled signals were removed by subtraction. Then, it is possible to observe the signal variation of AB couple system and MN couple system. Our results show that, in conventional clinical field strengths, this method can extract spectra of some strongly coupled metabolites, such as glutamate, myo-inositol, NAA and taurine. Moreover, this technique is easy to be realized by changing TE1 and TE2 parameters, and is therefore convenient for clinical usage. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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