1. Microwave-Assisted Efficient Synthesis of Aryl Chalcogenides Through C-H Functionalization of Arenes2. N-Chlorosuccinimide-Promoted Synthesis of Thiophosphates from Thiols and Phosphonates Under Mild Conditions
| Autor: | Yi-Chen Liu, 劉亦宸 |
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| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 In the first part of this thesis, microwave-assisted iridium-catalyzed meta C-H borylation followed by copper-promoted C-S or C-Se bond coupling reactions in one-pot was reported. This approach enables the syntheses of aryl thioethers and selenides in short reaction times (2.5 h). The system shows good functional group compatability, as chloro, trifluoromethyl, fluoro and pyridine groups are tolerated by the reaction conditions. Both aryl- and alkyl thiols were coupled smoothly to give the products with excellent regioselectivity at meta position. In the second part of this thesis, a very simple N-chlorosuccinimide-promoted synthesis of thiophosphates through the coupling of thiols and phosphonates is reported. Notably, the reactions were carried out in the absence of base. This system shows good functional group tolerance. Both aryl- and alkyl thiols were coupled smoothly with a broad spectrum of phosphonates to afford the corresponding thiophosphates in good to excellent yields. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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