Synthesis of 5-Amino-1,2,4-triazoles from Carbodiimides with Nitrilimines via 1,3-Dipolar Cycloaddition and Bioactivity Study
| Autor: | Fang-Chun Kung, 龔芳醇 |
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| Rok vydání: | 2014 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 102 An effective 1,3-dipolar cycloaddition was successfully developed for synthesis 5-amino-1,2,4-triazoles by reacting hydrazonoyl hydrochlorides (nitrilimines) with carbodiimides in the presence of triethylamine as a base catalyst. Carbodiimides can be adapted to the newly developed reaction condition, except for diphenyl carbodiimide. All of 5-Amino-1,2,4-triazoles were evaluated against a panel of human cancer cell lines in vitro, including lung carcinoma (NCI-H226), nasopharyngeal (NPC-TW01), and T-cell leukemia (Jurkat) cells. Based on the IC50, result, most of them provided the poor inhibitory potency. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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