Investigating the Characteristics of Biomolecular Additives on the Tribological Behavior of Artificial Joint Materials
| Autor: | Shu-Wen Chen, 陳淑文 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Ultra-high molecular molecular weight polyethylene (UHMWPE) and Co-Cr-Mo alloy are common artificial joint materials.Wear debris of UHMWPE will induce immune response of human body which leads to osteolysis.Moreover, it will accelerate the loosening of artificial joint and reduce the lifetime of artificial joints. The compositions of human synovial fluid are abundant. From previous studies, we found out that the key moleculars affecting the tribological behavior of artificial joints are albumin and hyaluronic acid. In this study, we applied the pin-on-disc friction tests to screen out the potential bio-molecular additives to reduce friction.We applied 25v/v% bovine calf serum as lubricant which is used in artificial joint simulator.Hyaluronic acid, carboxymethyl cellulose, alginic acid sodium, carrageenan are applied as the additives in BCS in this study. We investigated and analyzed the tribiological behavior of lubricants with various compositions. The result showed that alginic acid sodium is the most effective biomolecular additive. The lowest of friction of coefficient will be shown when adding 12.5mg/ml of alginic acid sodium. Furthermore, we investigated the difference in the lubrication characteristics of artificial joint materials when albumin solution was used as lubricant. The testing results show that the lubrication can be improved after adding the single molecule into albumin under boundary lubrication. Adding alginic acid could lead to the lowest friction of coefficient which is similar to the result when BCS was used as lubricant. Moreover, this study suggests that the most effective combination of lubricant composition is bovine calf serum containing 4.5mg/ml of alginic acid and 4.5mg/ml of carrageenan. It shall be further designed to run the artificial joint simulator tests to verify the phenomena observed in this study. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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