Development of porous polylactic acid for the soft tissue filling applications
| Autor: | Man-Ting Huang, 黃曼婷 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 The experimental research for the development of porous polylactic acid as a dermal stimulant, the main mechanism is implanted biomaterials by inducing inflammation, so that fibroblasts close, and then secrete collagen, reaching the dermis proliferation purposes. In addition to filling effect can be achieved, and can be extended to fill the prescription.Because of its biodegradable, bioabsorbable and biocompatible nature, has been widely used in biomaterial applications. Use of polylactic acid, the development of porous particles, while establishing a porous polylactic acid particle processes, complete determination of the nature and identify the best conditions, the material on cytotoxicity detection. Polylactic acid with a gel-forming injectable soft tissue filling agent is injected into the body to fill the necessary parts, such as fold part. Currently on the market, often with hydroxyapatite and polylactic acid, etc. The problem is that the existing shortcomings material fabrication process, it is different particle size, surface morphology and the material in the filling material irregularities within the dispersion is not well, resulting in uneven dermal irritation, locally excessive reaction, clinical phenomena such as pimples and granulation tissue swelling. To enhance the application, obtained through the process of polylactic acid particles porous filling material made with the development of the brand-Sculptra listed for comparison, for example: the appearance, viscoelasticity, dispersion and so on. Finally, the selected adipose stem cells and polylactide porous filling material mixed, testing biocompatibility. Therefore, the purpose of the experiment is to develop a uniform size of the porous morphology of polylactic acid particles to improve the existing dermal stimulation uneven fill effects, and optimizing fill formulations, the effect of the natural softness. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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