Expression of Heat Shock Factor 1 in oral squamous cell carcinoma
| Autor: | Wen-Ren Lin, 林文仁 |
|---|---|
| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Background HSPs function as molecular chaperones to restore protein homeostasis. Heat Shock Factor 1(HSF1) is an 82-k Da transcription factor that is strongly activated in response to heat shock and other forms of environmental and chemical stresses. HSF1 is responsible for expression of a large class of heat shock proteins, which protect cells from damage as a result of cellular insults, heat chock and oxidative stress. The tumor cell is usually exposed to the harsh environment. Heat Shock Factor 1(HSF1), master regulator of heat-shock proteins, facilitates the survival and proliferation of tumor cells under such conditions. Many types of highly malignant tumors express high levels of HSF1, including prostate, lung, colon, pancreas, cervix and meningioma. Our study shows that the over expression in OSCC and the correlation with the clinical, pathological parameters, and survival time. Materials and Methods Examined in this study were 92 specimens diagnosed as oral squamous cell carcinoma (OSCC) and 25 specimens of oral epithelial dysplasia (OED). 35 cases of normal oral mucosa (NOM) were also observed for comparison. With a HSF1 monoclonal antibody, immunohistochemistry (IHC) stain was performed for detecting expression of HSF1 in these tissue sections. The degree of positive staining was recorded and graded as labeling index (LI). Finally, the correlations between expression of HSF1, clinical and pathologic parameters, and the overall survival of OSCC patients were analyzed statistically via Chi-square test, Cox proportional hazard regression model, and Kaplan-Meier plots. Results The labeling index of HSF1 was significantly higher in OSCC specimens (p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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