A study of interhemispheric structure-function relationships in healthy human brain using resting-state fMRI and diffusion spectrum imaging tractography
| Autor: | Hsin-Long Hsieh, 謝欣容 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 The aim of this study is to well-knit approach to better understand the structure-function relationships in healthy human brains using the simplest system as a model to investigate the relationships between interhemispheric structural connectivity and functional connectivity and the characteristics among different lobes in the brain. To understand the structure-function relationships in human brain, this study focuses on the corpus callosum, the simplest system in human brain. We recruited 20 young healthy right-handed adults in this study. Scanning was performed on a 3T MRI system, consisting of structural, functional, and diffusion MRI. Structural connectivity was defined as the number of connected tracts terminating between two regions divided by the total number of corpus callosal tracts and functional connectivity was defined as the partial correlation coefficient of time courses between two distinct regions. Structure-function relationships were computed by correlating functional connectivity with structural connectivity. We found weak to moderate structure-function correlations in the corpus callosum. In addition, homotopic and heterotopic connections showed distinct strengths of structure-function correlations. These results indicate the topology of the corpus callosum is associated with structure-function relationships. Moreover, functional connectivity can be explained by structural connectivity to some degree, such that interhemispheric functional connectivity may involve contributions from other physical connections in addition to the corpus callosum and hormone effect. In this study, we use the simplest system corpus callosum to confirm that instead of strong degree of structure-function relationship, the structural connectivity is moderately correlated with the functional connectivity, which is the consistent result across a wide variety of methods. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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