Asymmetric Addition of Dimethylzinc to N-(P,P-Diphenylphosphinoyl) Imine Catalyzed by a Rhodium-Diene Complex toward the Synthesis of NPS-R-568
| Autor: | WU, Wen-Chien, 吳文茜 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 This process offers chiral arylmethylamines with a N-P,P-diphenylphosphinic protecting group from asymmetric addition of dimethylzinc to N-(P,P-diphenylphosphinoyl) imine in the presence of catalyst in situ generated from rhodium (I) and chiral diene ligand 65a, giving the 1,2-addition products in good yields and excellent enantioselectivities (ee value up to 98%) for various aldimines. The synthetic utility of this protocol was demonstrated in the preparation of (S)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl) propan-1-amine, a calcimimetic agent. Keyword：chiral diene ligand、Rhodium、dimethylzinc、N-(P,P-diphenylphosphinoyl) imine |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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