Epidemiologic of Juvenile Idiopathic Arthritis and Risk Associated with Its Treatment: A Population-Based Cohort Study in Taiwan
| Autor: | Lai-Zhen Zhuang, 莊來鎮 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Juvenile idiopathic arthritis (JIA) is a heterogeneous group of conditions defined as inflammatory arthritis occurring in children under 16 years old, it is the most common rheumatic disease in children to be the cause of short and long term disability in children with decreased daily function and quality of life. The treatments of JIA include a combination of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease modifying anti-rheumatic drugs (DMARDs) of which methotrexate (MTX) is most commonly used, and biological therapies such as tumor necrosis factor alpha (TNF-α) inhibitors. TNF-α inhibitors have been shown to be highly effective in the treatment of JIA. However, there was some safety issues about a possible increased risk of bad outcome associated with their use, such as malignancy (especially lymphoma), tuberculosis, uveitis, and infection. We found a incidence rate of JIA with the value 15.7 per 100,000, and the prevalence rate of JIA with the value 29.8 per 100,000 in Taiwan from 2002 to 2008. We found a higher risk of malignancy, uveitis, and infection among the JIA patients compare to non-JIA cohort, a significantly increased 3.1-fold rate of uveitis and 1.7-fold rate of infection among JIA patients with MTX use, an increased 4.1-fold rate of uveitis among JIA patients treat with TNF-α inhibitors. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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