1. Rhodium-Catalyzed Carbon-Sulfur Bond Cross-Coupling Reaction in water2. Synthesis of Aryl Selenides and Their Application in Bioactivity

Autor: Ling-Chien Chang, 張綾倩
Rok vydání: 2013
Druh dokumentu: 學位論文 ; thesis
Popis: 101
In the first part of this thesis, we report that a combination of rhodium salt with BINAP can be served as a powerful catalyst for coupling thiols with aryl iodides in water. Moreover, this catalytic system is allocable to couple vinyl halides with thiols. The second part of this thesis, we found that C-Se bond can be formed smoothly under transition-metal-free conditions. First, indoles are introduced as the coupling partners to couple with diselenides, giving the corresponding aryl selenides in good to excellent yields; we also studied the bioactivity of these compounds. Second, we discovered that the electron-withdrawing-containing aryl halides and nitrogen-containing heteroaryl halides can be smoothly coupled with aryl selenides to form diaryl selenides under metal-free conditions. Notably, either 2 or 3 halogenated pyridines can be conducted with diselenides to provide the coupling products in good yields.
Databáze: Networked Digital Library of Theses & Dissertations