Effects of Substance Use and Alcohol Metabolizing Genes on Second Primary Cancer of Upper Aerodigestive Tract
| Autor: | Yun-Ju Hung, 洪韻如 |
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| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Background: The medical technique is in advance in recent years, but it does not improve the survival rate of the patients with upper aerodigestive tract cancer. The main reason is the occurrence of second primary cancer. Purpose: The aim of the present study was to explore the effect of substance use and alcohol metabolizing genes on the incidence and diagnostic age of second primary cancer of upper aerodigestive tract. Furthermore, we analyzed the association between second primary cancer of upper aerodigestive tract and death. Material and methods: This was a concurrent cohort study. 399 patients with upper aerodigestive tract cancer were recruited in Kaohsiung Medical University Chung-Ho Memorial Hospital from June, 1992 to April, 2011. When the patients were diagnosed as first primary cancer of upper aerodigestive tract, we collected their blood samples, consulted their clinical medical records, and interviewed them with questionnaire. And then the patients were followed up to ascertain the occurrence of second primary cancer of upper aerodigestive tract and the occurrence of death. Results: 59 out of the 399 recruited patients suffered from second primary cancer of upper aerodigestive tract when the study ended. The incidence risk of metachronous second primary cancer in betel-quid lifetime exposure ≧800 quid-year chewers was 3.8 (95% C.I. of aHR: 1.1-13.3) times higher than in non-chewers. The incidence risk of second primary cancer of oral cavity in betel-quid starting age |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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