Effect of epigallocatechin gallate on acetaminophen metabolism in rats
| Autor: | Chen-Hui Chang, 張晨慧 |
|---|---|
| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Acetaminophen (APAP) is a widely used analgesic and antipyretic drug. However, when excessive doses of APAP are ingested, APAP can convert into reactive electrophile metabolites though CYP450 exzymes, which causes severe liver injury. The most abundant tea Polyphenols in gean tea is epigallocatechin gallate (EGCG). Studies indicate that EGCG have antioxidant activities and reduce the chemicals-induced liver injury. To investigate the effect of EGCG on drug-metabolizing enzymes, liver transporters and the metabolism of acetaminophen in rats, two experiments were conducted. Experiment I : To investigate the effect of EGCG on drug-metabolizing enzymes and oxidative stress in rat liver, male Sprague-Dawley rats were fed a chow diet (control group) and a diet containing 0.18% or 0.54% EGCG (w/w) for 1 week and 4 weeks. Results showed that hepatic CYP3A activity was decreased siginificantly (p |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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