Studies on the Chemical and Bioactive Constituents of Stellaria aquatica (L.) Scop.
| Autor: | Hsin Ying Huang, 黃馨瑩 |
|---|---|
| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Stellaria aquatica L. Scop., one species of Stellaria plants (Caryophyllaceae), is mainly growing in temperate regions of northern hemisphere. In the previous research, flavonoids, β-carbolines and cyclopeptides were isolated from this genus. In present study, the MeOH extracts was partitioned in n-BuOH, n-Hexane and H2O. Of these, the n-BuOH, n-Hexane and water soluble layers showed 62.57 %, 44.59 % and 2.98 % inhibition against superoxide generation of human neu- trophils induced by fMLP at 10 µg/mL. Therefore, the n-BuOH layer was further studied on their chemical and bioactive compounds by column chromatography. Herein, twelve compounds were isolated from the n-BuOH layer and the structures were determined as 3-methoxy-4-hydroxydihydrocinnamic acid methyl ester (1), methyl 2-benzamido-3-phenylpropanoate (2), 4-quinolone (3), 2-methoxy- 1,4-dihydroxy-benzene (4), dihydroferulic acid (5), syringic acid (6), vanillic acid (7), N-benzoyl-L-phenylalaniol (8), aurantiamide (9), acacetin (10), p-hydroxybezoic acid (11) and corchoionol C (12) by spectroscopic analysis. Among these compounds, compound 2, 6 and 10 showed inhibition against superoxide generation of human neutrophils induced with fMLP with IC50 values of 12.06, 23.24 and 0.88 μM. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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