The Role of Aberrant Epigenetic Silencing of NR4A3 and LOXL4 in Gastric Cancer
| Autor: | Li-Han Zeng, 曾莉涵 |
|---|---|
| Rok vydání: | 2013 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 101 Gastric cancer is the second leading cause of cancer worldwide. Epigenetic silencing of tumor-suppressors has emerged as an important underlying mechanism in the gastric carcinogenesis. Previous studies showed that infection of H. pylori activates JAK/STAT3 signaling pathway in gastric cancer. However, the role of this aberrant signaling remains unclear. We hypothesized that activation of JAK/STAT signaling leads to epigenetic silencing of STAT3 target genes in gastric cancer. In our previous study, we has demonstrated that a constitutively active STAT3 led to epigenetic silencing of its downstream target genes, NR4A3 and LOXL4, via promoter CpG island hypermethylation in MKN28 cells where JAK/STAT signaling is intact. Ectopic expression of NR4A3 in AGS cells where JAK/STAT signaling is constitutively activated reduced cancer cell growth in colony formation assay (P |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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