Anti-Fatigue Activity of Extracts of Polygonatum altelobatum Hayata
| Autor: | Jon-Kway Huang, 黃榮貴 |
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| Rok vydání: | 2012 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 Polygonatum altelobatum Hayata plants of the genus Polygonatum Liliaceae, is a Taiwan''s endemic plant, strengthen lung function, lowering blood sugar, strong bones and muscles, antifatigue and delay many efficacy of human aging. The present study is to investigate the effect of aqueous extracts from root of Polygonatum altelobatum Hayata (TPAE) on amelioration of exercise-induced fatigue and oxidative stress in rats. Sprague-Dawley (SD) rats were divided into four groups including control (fed with drinking water) and three groups of different doses of TPAE (75, 150 and 375 mg/kg.bw). An exhaustive exercise test on a treadmill and the measurement of biochemical parameters related to fatigue were carried out after eight weeks. The results revealed that TPAE could extend significantly the endurance time to exhaustion, as well as decreasing the blood lactate and blood urea nitrogen (BUN) contents. Malondialdehyde (MDA) level of rats in PAHE treated groups were significantly decreased compared with that in the control group, while superoxide dismutase (SOD) and catalase (CAT) were significantly increased with comparison to that in the control group. The overall results indicated that PAHE had anti-fatigue activity with effective prevention of oxidative stress after exhaustive exercise and could elevate the exercise tolerance. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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