Investigations of Prognostic Factors in Childhood AcuteLymphoblastic Leukemia:A Multi-Center Analysis in Taiwan

Autor: Yung-Li Yang, 楊永立
Rok vydání: 2011
Druh dokumentu: 學位論文 ; thesis
Popis: 100
Background: Acute lymphoblastic leukemia (ALL) is the most common pediatricmalignancy and accounts for 25% of childhood cancers. ALL is thought to originatefrom various important genetic lesions in blood-progenitor cells that are committed todifferentiate in the T-cell or B-cell pathway, including mutations that impart thecapacity for unlimited self-renewal and those that lead to stage-specific developmentalarrest. Cure rates have improved dramatically over the past 40 years, with 5-year overall survival rates increasing from
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