ChemiRs - Web App for Chemicals, MicroRNAs and Human Health
| Autor: | Yun-Cheng Tian, 田耘政 |
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| Rok vydání: | 2011 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 MicroRNAs (miRNAs) are about 22 nucleotides, non-coding RNAs that affect various cellular functions, and play a regulatory role in different organisms including human. Until now, about 1500 miRNAs in human have been discovered and registered, but still lack of information or algorithms to reveal the relationships among miRNAs, environmental chemicals and human health. Chemicals in environment affect our health and daily life; some of them lead to diseases by inferring biological pathways. To develop a creditable method for predicting relationships between miRNAs and chemicals, the database can not only compare the gene lists affected by chemicals and miRNAs, but also use curated pathway to find possibly interactions. The web server we describe here is an online system for evaluating the interactions/relationships between chemicals, miRNAs and pathways. Here, we manually retrieved the associations of miRNAs and chemicals from literatures. We built an online web server system, which contains miRNA IDs, disease names, MeSH IDs, chemical IDs, gene names, pathways, and the literature PubMed IDs. We connected each miRNA to miRBase and every current gene symbol to HUGO Gene Nomenclature Committee (HGNC) for detailed genome annotations. The pathway information in human are also provided from KEGG and Reactome database. The information about gene ontology is queried by SQL from GO Online SQL Environment (GOOSE) built by AmiGO lab. With a user-friendly interface, the web application is easy to use. Association analyses of miRNAs and chemicals will help us the understanding of the pathogenesis of such chemical components. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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