Anti-fatigue effects of an ethanolic extract from Antrodia camphorata
| Autor: | Huei-Ru Yang, 楊惠茹 |
|---|---|
| Rok vydání: | 2011 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. The purpose of this study was to determine the fatigue-alleviating effects of AC on endurance capacity in weight-loading and exercised mice. Thirty male ICR mice (5-week-old) were divided into three groups (n=10 per group): (1) vehicle; (2) 50 mg/kg of AC (AC-50); (3) 200 mg/kg of AC (AC-200). Mice were given orally either vehicle or AC by gavage for 7 days. The AC group showed a significant increase (p < 0.05) in liver glycogen (20.70 ± 1.64, 21.59 ± 1.55 v. s 14.28 ± 2.26 mg/g) and muscle glycogen (2.07 ± 0.08, 2.20 ± 0.07 v. s 1.72 ± 0.05 mg/g), forelimb grip strength (142±1, 142±4 v. s 125±5 g), and swimming time to exhaustion (113.6±12.1, 152.8±9.8 v. s 70.9 ±15.7 min) as compared to the vehicle group. Blood lactate ((5.9±0.4, 5.2 ±0.3 v.s 7.5±0.4 mmol/L) and ammonia (283±20, 257±15 v.s 438±18 μmol/L) levels in the AC groups were significantly lower (p < 0.05) than in the vehicle group at 15 min after a swimming test. Moreover, the activity of plasma creatine kinase (CK), a marker of muscular damage, was significantly decreased (p < 0.05) in the AC groups than vehicle group after swimming (33±3, 26±2 v.s 56±8 U/L). These results suggest that increase in swimming endurance by the administration of AC is caused by an increase in deposition of liver and muscle glycogen as an energy source. AC may have potential for use in ergogenic and anti-fatigue activities. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|