Exploration of the correlation between children general anesthesia time and the central nervous system diseases
| Autor: | Ya-Chang Cheng, 鄭雅靜 |
|---|---|
| Rok vydání: | 2012 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 Goals: Anesthesia is a complex pharmacological reaction. Whether general anesthesia will affect central nervous system in children is always the concern. The purpose of this study is to determine whether the duration of anesthesia have an impact on the certral nervous system at different age group of children under the database analysis from the National Health Insurance. Methods:Under "National Health Insurance Research Database of the year 2000, 1 million samples were collected. From 1997 to 2009,children who underwent anesthesia before the age of six was the sample group.While the control group which who have not underwent anstheaia was matched based on gender and age. Results: Total 6608 children underwent anesthesia before age of six in 1997-2009.Above them, intratracheal intubation which accounts 77.9% of all general anesthesia is the highest method .The mean age of anesthesia is 3.6 years old .The incidence rate of central nervous system diseases in children who have anesthesia is 10.75 per1000 person- years with odds ratio of 1.35 (95% CI= 1.23-1.47)which was higher than children without anesthesia (8.02 per 1000 person- years). In Semi-opened or semi-closed mask method group, the cumulative incidence rate of central nervous system diseases is 10.61 per1000 person- years with risk odds of 1.30 (95% CI = 1.09-1.54).In semi-closed or closed intratracheal intubation method group, the cumulative incidence rate of central nervous system diseases is 10.83 per1000 person- years, with odds ratio of 1.36 (95% CI= 1.23-1.50). Conclusion: The duration of anesthesia is not statistically significant to the incidence rate of central nervous system disease. The smaller group number and the smaller gap of grouping age were considered the cause. Both mask and intubation methods of general anesthesia have the higher odds ratio to central nervous system diseases than those who doesn’t have anesthesia. Recommendation: This study was based on the database of the National Health Insurance database.If more detailed grouping age was disclosed,the statistical result may have the difference. In addition, the Government could advocates more on the campaign of regular health examination below the age of six, so that all parents would take their children to the medical institutions for regular health examination. Anesthesia also should be annotated on the NHI manual. Therefore doctors,who assess the development milestone will notice the abnormalities earlier,and will manage them earlier.Regular follow up of physical and mental development would reduce the severity of central nervous system diseases. In that way,the life quality in those children and their parents would improve.The medical costs would also declined. |
| Databáze: | Networked Digital Library of Theses & Dissertations |
| Externí odkaz: |
|