The effects of operational parameters to avoid sampleleakage and to minimize dispersion in microfluidicbiochip channels.AndThe effects of buffer electrolytes in electroosmoticflows.
| Autor: | MIN-HUI YANG, 楊閔惠 |
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| Rok vydání: | 2012 |
| Druh dokumentu: | 學位論文 ; thesis |
| Popis: | 100 Microfluidic biochipsare a group of biochemical analysis tools using electroosmotic flows as a pumping mechanism for sample transfer. The electrokinetic transport phenomena are very important for designing and controlling microfluidic biochip. This study investigates the dispersion effects of samples associated with the four end-point voltages and the width ratios of cross-section channels to improve the analysis resolution and detection sensitivity. This dissertation employs numerical simulations to study the mass transfer, the injection leakage, and the dispersion of loaded samples. We first investigated the relationship between the sample leakage and the velocity regarding the surface potential, and then explored the other effects of the flow field influenced by the channel width ratio, end point voltage ratioand buffer ionic strength. The results showed that the upstream velocity must be faster than the downstream velocity to avoid sample leakage and previous parameters influencing the upstream and downstream velocity difference |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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